8). Check out Bootcamps Yes or nah? Corporate Financial Managementspring term (BS 2508) Second year of undergraduate. Much attention has b Fluorescent probes targeting specific organelles are useful tools for understanding their intracellular behaviors. ), no. Have any problems using the site? Google Scholar. Runtime Collective Limited (trading as Brandwatch). Nat. Commun. Skoglund, P. et al. Djindjian, F. Territories and economies of hunter-gatherer groups during the last glacial maximum in Europe. 1a, and the y-axes report time in thousand years before present (kBP). The nucleolus is the largest substructure in the nucleus, where ribosome biogenesis occurs. In the MDS plot, the Le Piage II individual falls particularly close to individuals belonging to the Fournol cluster, suggesting a local genetic continuity of this ancestry during the LGM (Supplementary Fig. This, together with the evidence of Villabruna ancestry in El Mirn 19ka, further suggests that this genetic discontinuity could be the result of palaeogeographic and palaeoecological transformations connected to the LGM32, rather than to the BllingAllerd warming period4,15 (14.712.9ka). Ancient genome-wide DNA from France highlights the complexity of interactions between Mesolithic hunter-gatherers and Neolithic farmers. View Tina Zhang's business profile as Brand Specialist at Dymind Biotechnology. Radiocarbon 55, 163177 (2013). First up is the MIT researcher and YouTuber Jordan Harrod. 31, 24842493.e7 (2021). In central Europe, admixture with ANF ancestry became highly common but not ubiquitous, indicating the co-existence of hunter-gatherer and farmer societies without admixing for several hundred years. Modern humans have populated Europe for more than 45,000 years1,2. Rep. 11, 15005 (2021). A draft sequence of the Neandertal genome. Life and career Early life. The newly defined Fournol cluster is closely related to Aurignacian-associated individuals from Belgium dated to 35ka (Goyet Q116-1 and the newly reported Goyet Q376-3 individual). The LGM could thus have created a corridor south of the Alps for east-to-west human movements that genetically connected hunter-gatherer populations from the Balkans to Iberia, possibly also via dispersals along existing lower-sea-level coasts32. Ontario Institute for Cancer Research Toronto, ON. In this study, we analyse 356 ancient hunter-gatherer genomes including new genomic data of 116 individuals dated to 355ka alongside a novel contamination-estimation method based on runs of homozygosity. This genetic signature is shared among individuals associated with the archaeologically defined Gravettian culture (3326ka) in central and southern Europe and seemingly disappeared after the Last Glacial Maximum4 (LGM). As recommended, we analysed individuals with over 400,000 SNPs called on the 1240k panel101 and we called ROH longer than 4cM (Supplementary Data 3.B). 132, Tables 14 and references. The generation time is set to 29 years and the error bars show the SE of the admixture date estimated from jackknife resampling (n=22 autosomal chromosomes). YourCourse Certificatehas no expiration date. Google Scholar. 14, evac045 (2022). Reviews. Publications 4. h-index 3. In the video above, she explains the two major components of big data: data warehousing and data science. Nucleic Acids Res. The IntCal20 Northern Hemisphere radiocarbon age calibration curve (055 cal kbp). Look here to get updated on my recent favourite books, animes, filming equipment and more! Tina Huang Data Scientist. The key areas to focus on when getting started in data science [6:01] Tina's five steps to consistently doing anything [11:55] Tina's day-to-day life as a data scientist at one of the world's largest tech companies [20:02] How Tina's computer science background helps her work [26:20] Traditional banking culture vs big tech [32:12] tina huang data science Explained in Instagram Photos. 5 Cliches About computer science flow chart You Should Avoid, What Freud Can Teach Us About brief candle in the dark my life in science. Product development is a huge and complex set of processes that rests on many moving parts, lots of hypotheses testing, and ultimately many decisions. "Ice Age survivors." Join now Sign in . The newly reported individuals with over 15,000 SNPs on the Human Origins dataset are shown in black-outlined and filled symbols, as illustrated in the legend on the right, while representative ancient genomes are shown in outlined symbols, as illustrated in the legend at the bottom of the PCA. Required fields are marked *. Overall, the literature suggests that Chinese Canadian students demonstrate high levels of achievement and that this academic success is associated with factors such as stronger feelings of ethnic identity, better English language skills in the family, Chinese . Check out The data science resume that got me my FAANG job and subscribe to Tina Huangs YouTube channel. 12). Nature 570, 182188 (2019). It is generated automatically, and you can download, view, and share it at any time. Science 360, 548552 (2018). a, MDS plot of pre-LGM individuals. Sydney, Australia. The youngest individual carrying large portions of hunter-gatherer ancestry in the analysed dataset is from Ostorf in northern Germany, dated to around 5.2ka (>90% Oberkassel clusterplus Sidelkino-clustercomponents)(Supplementary Data 3.F). Int. Tina Huang. The lsqproject: YES parameter was used to minimize the effect of missing data in ancient individuals. Bioinformatics 20, 289290 (2004). In it, we laugh while discussing how to get started in data science and her learning/productivity tricks.Tina: Creates YouTube videos with millions of views on data science careers, learning to code, SQL, productivity, and study techniques. Is a data scientist at one of the world's largest tech companies (she keeps the firm anonymous so she can publish more freely). Previously worked at Goldman Sachs and the Ontario Institute for Cancer Research. Holds a Masters in Computer and Information Technology from the University of Pennsylvania and a bachelors in Pharmacology from the University of TorontoIn this episode, Tina details: Her guidance for preparing for a career in data science from scratch. Her five steps for consistently doing anything. Her strategies for learning effectively and efficiently. What the day-to-day is like for a data scientist at one of the worlds largest tech companies. The software languages she uses regularly. Her SQL course. How her science and computer science backgrounds help her as a data scientist today.Todays episode should be appealing to a broad audience, whether youre thinking of getting started in data science, are already an experienced data scientist, or youre more generally keen to pick up career and productivity tips from a light-hearted conversation.Thanks to Serg Mass, Brindha Ganesan and Ken Jee for providing questions for Tina in Ken's case, a very silly question indeed.The SuperDataScience show's available on all major podcasting platforms, YouTube, and at SuperDataScience.com. We provide five novel insights into the genomic history of hunter-gatherer populations over a time span of 30,000 years from the Upper Palaeolithic to the Neolithic. The f3-statistics were calculated with qp3Pop 435 in ADMIXTOOLS 5.1 package103. In the meantime, to ensure continued support, we are displaying the site without styles In other cases, you may have to create a more complex database structure (such as SQLite). 5b and Supplementary Figs. Rep. 10, 21931 (2020). Every Thursday, I share insights from books, learning & productivity tips, and a coding challenge. Huang's parents immigrated to New York City where her two older brothers . Opin. This raises the possibility that the replacement by the Oberkassel cluster and the formation of the Sidelkino cluster might have been the result of population expansions influenced by the abrupt warming during the BllingAllerd interstadial4,24. Ancient human genomes suggest three ancestral populations for present-day Europeans. The two 14ka Oberkassel individuals mark the earliest presence of WHG ancestry north of the Alps, which we therefore rename the Oberkassel cluster(hereafter, Oberkassel cluster or ancestry), using the name of the oldest reported individual to date carrying such ancestry with more than one-fold coverage, for consistency4. Data warehousing is a field where you often have to deal with a lot of raw data. This is further validated by f4-statistics of the form f4(Mbuti, Arene Candide 16; Goyet Q-2, Magdalenian-associated individuals), which is significantly positive only for El Mirn, whereas all other tested individuals and Goyet Q-2 are symmetrically related with respect to Arene Candide 16 (Supplementary Fig. Modern humans left sub-Saharan Africa at least 60 thousand years ago (ka), and during their initial expansion into Eurasia, they genetically mixed with Neanderthals, resultingin 23% Neanderthal ancestry in the majority of present-day non-African populations5. Archeol. Write a sharp and effective resume in minutes and get noticed by employers. Instead, in southern Europe, a distinct hunter-gatherer genetic profile was found as early as 17ka in individuals associated with the Epigravettian culture15 (2412ka, from the Italian peninsula to the southeastern European Plain across the Balkans). Radiocarbon 51, 337360 (2009). Quat. Genetically, however, the populations from western and southwestern Europe (today's France and Iberia) differed from contemporaneous populations from central and southern Europe (today's Czech Republic and Italy). University Universit Chouaib Doukkali; . Genome Res. You also get a peek at Tina's Resume, so I don't think you want to miss out on that. Life During Adulthood: Should One Get Credit Cards? In this video, I had the opportunity to talk with Tina Huang, a Data Scientist at one of the FAANG companies. My name is Tina and I'm a data scientist and YouTuber. & Nielsen, R. ANGSD: analysis of next generation sequencing data. The levels of contamination from modern human DNA were estimated on the basis of mitochondrial DNA (mtDNA), X chromosome and autosomal DNA, and with a haplotype copying model that is extended here to autosomal data in runs of homozygosity (ROH) (Methods, Supplementary Information, sections2 and 3, Supplementary Figs. Its no surprise that she was selected for the Code Cup, a yearly event where students from all over the world compete in coding challenges. The analysed genomes also show that the descendants of these Epigravettian inhabitants of the Italian peninsula spread across the rest of Europe about 14,000 years ago, replacing populations associated with the Magdalenian culture. In a rotator, samples were digested for at least 16h at 37C, and for pre-treated samples this was followed55 by an additional hour at 56C. The idea of data warehousing is to store large amounts of data in a way that makes it easier to extract and analyse. Klaric, L., Goutas, N., Laccarire, J. In particular, the 13ka Pradis 1 individual from northeastern Italy represents the most basal lineage compared to all other Epigravettian-associated individuals, including the older Tagliente 2 and Villabruna genomes from northern Italy (group 1). The genomic similarity of the Oberkassel cluster to Arene Candide 16 in northwestern Italy might imply that Epigravettian-associated ancestry spread from the south to central Europe passing through the western side of the Alpine region. Article No need to do it alone our community of learners and instructors is there for you. Us Too. Check it out! This Villabruna ancestry(hereafter, Villabruna cluster or ancestry) showed connections to ancient and present-day Near Eastern populations4,16, but the mode and tempo of its expansion into the Italian peninsula remain unexplored. In this admixture graph, the lineage related to Zlat k splits more basally than the Bacho Kiro IUP group, who contributes to Tianyuan, UstIshim and Goyet Q116-1 (indicated with red lines), but not to the Sunghir group. For the SNP associated with light eye colour (HERC2/OCA2 (rs12913832)), individuals from the Villabruna cluster,Oberkasselcluster, Baltic HG and SHG groups show high frequencies of the derived allele (>90%), which is responsible for the green or blue eye phenotype, whereas Sidelkinocluster, Ukraine HG and Iron Gates HG groups show low occurrence of this allele (1025%). Publication: Huang T, Reimand J. Network-rewiring mutation in kinase signaling networks are informative of cancer patient. Weissensteiner, H. et al. First, we show that individuals associated with the Gravettian culture across Europe were not a biologically homogeneous population. Details are provided in Data S2.B. This channel is about data science, learning, and productivity. Google Scholar. Most Popular #86731. van de Loosdrecht, M. et al. In central-western Europe, Gravettian-associated individuals from Goyet show affinity to both clusters. This results in a tree with 57 newly reported and previously published ancient individuals while present-day sequences are collapsed in the major Y-chromosome haplogroups (the most basal lineages are not shown). (2023, March 1). Tina Huang. 2 The distribution of mtDNA and Y-chromosome haplogroups among different hunter-gatherer groups. 16, 224 (2015). This means you will have no set time limit for completing any of the modules or assignments. Late Pleistocene human genome suggests a local origin for the first farmers of central Anatolia. Then we merged the genotypes from different libraries of the same individual, by randomly picking alleles from available genotype calls, using a custom script. Cold Spring Harb. Ongoing symptoms 3 months after infection by SARS-CoV-2 are well described as long COVID and have become a global health concern [1], [2].Fatigue and dyspnea are the two most common symptoms after infection by SARS-CoV-2 and low physical performance impacting daily activities has been described for up to 6 months after infection [3]. View Tina_Huang_Resume_i.pdf from HCI 445 at DePaul University. You have to deal with large datasets; however, you have to do your work in a way that makes sense to your team. The labels in italic denote previously published individuals without new data generated in this study. Consultant - October 2015 to June 2016. The pre-40kagroup and theFournol and Vstonice clusters are marked as shaded areas in different colours. In practice, we use machine learning in different conjunctures. Schmitt, T. Molecular biogeography of Europe: Pleistocene cycles and postglacial trends. Prfer, K. et al. Quat. To bind DNA, silica columns for high volumes (High Pure Viral Nucleic Acid Large Volume Kit (Roche)) were used. Article Previous studies identified two different genetic compositions in Magdalenian-associated individualsthe GoyetQ2 cluster including central-western European genomes dated to around 15ka (from France, Belgium and Germany), and the ancestry of the El Mirn individual from Spain4,14 from around 19ka. Newsletter, I hold a Bachelor's degree at the University of Toronto where I studied pharmacology. At this startup dedicated to b2b marketing, we, the data team formed by 2 people, are organizing all the data from zero and looking for their real value. The genetic history of Ice Age Europe. Its not just the top 200 that this competition attracts, but anyone interested in data science. In general, the whole point of data warehousing is to get the data from your source to your target. Wren, C. D. & Burke, A. Habitat suitability and the genetic structure of human populations during the Last Glacial Maximum (LGM) in Western Europe. Nature 555, 197203 (2018). It encourages me to go out and re-learn SQL and excites me for the mock interviews to come. Leveraging the substantially increased sample size, we investigated genetically distinct hunter-gatherer groups for allele frequencies at selected loci that are known to be associated with specific phenotypic traits in present-day Europeans (Fig. Conversely, individuals in the Sidelkino cluster are genetically closer to AG3 than Tutkaul 1. Tina Huang Profile page. The Sidelkino ancestry also emerged around 14ka with its first direct evidence in eastern Europe43 dated to 13ka. ), no. Notably, this genetic distinction coincides with dissimilarities in mortuary practice among genetically analysed Gravettian-associated individuals from different parts of Europe. Biol. Cuando se ampla, se proporciona una lista de opciones de bsqueda para que los resultados coincidan con la seleccin actual. Evol. Ace the SQL part of any data science job interview and get hired. Lipson, M. et al. PubMed Central The emergence of hunter-gatherer pottery in the Urals and West Siberia: new dating and stable isotope evidence. Natl Acad. Happy International Womens Day! & Posth, C. Latest trends in archaeogenetic research of west Eurasians. Tina has 11 jobs listed on their profile. Next, we investigated the genetic relationships between Epigravettian-associated individuals across the Italian peninsula, by reconstructing a phylogeny based on a matrix of pairwise f2 genetic distances (Fig. 4a and Supplementary Data 3.C). Max Planck Institute for Evolutionary Anthropology. TV Actress. Radiocarbon 62, 725757 (2020). 3,528. J. Commun. Known to have been the coldest phase of the last Ice Age, the LGM is considered to have caused a demographic decline in large parts of Europe10, with populations retracting to southern latitudes as attestedfor exampleby the contemporaneity of the Solutrean culture (2419ka) in the Iberian peninsula and southern France. received support from the Estonian Research Council grant PUT (PRG243). Nat. Both newly sequenced genomes from Solutrean-associated individuals (Le Piage II (23ka) from southwestern France and La Riera (level 14, 21ka) from northern Spain) show a generalized affinity with members of the Fournol and GoyetQ2 clusters in outgroup f3-statistics (Supplementary Data 2.A). 2a). This might also explain the genetic uniformity of the Oberkassel cluster across large parts of western Eurasia but genomic data from between 15 and 14ka is needed to understand the exact dynamics of this turnover. Despite this wide geographical range, it is not clear whether different groups associated with this culture originated from a common source population and how those groups were genetically related to each other. Check out Why is Burnout So Common in Tech? 7, eabd6535 (2021). Article I also have a newsletter called Boop's Keyboard! The images or other third party material in this article are included in the articles Creative Commons license, unless indicated otherwise in a credit line to the material. Genetic sexing revealed 78 maleindividuals and 38 femaleindividuals (Supplementary Fig. Dev. Double-stranded DNA libraries were built from 25l of DNA extract, without the presence of uracil DNA glycosylase (ds_nonUDG) or in the presence of uracil DNA glycosylase (ds_halfUDG), following a double-stranded UDG-half library preparation to reduce, but not eliminate, the amount of deamination-induced damage towards the ends of ancient DNA (aDNA) fragments58. Now we have the founder and CEO of YSYS, Deborah Okenla. A negative and cave bear positive controls were included. My name is Tina and I'm a data scientist and YouTuber. This is also supported by f4-statistics of the form f4(Mbuti, Fournol 85; Sunghir, test), which are significantly positive for all the individuals included in the Vstonice cluster (Supplementary Data 2.B). Trans. Curr. Tina Huang, born on October 28, 1981, is an American stage and television actress of Taiwanese descent known for her recurring roles in Rizzoli & Isles and for her semi-regular role as Melinda Trask on the NBC soap Days of Our Lives. We show that all analysed Epigravettian-associated individuals carry a homogeneous Villabruna ancestry, with the intra-group genetic structure mainly determined by their geographical, and not temporal, distribution. To gain an overview of the genomic background of European hunter-gatherers before the LGM, we used multidimensional scaling (MDS) to plot a dissimilarity matrix of pairwise outgroup f3-statistics in the form 1f3(Mbuti; pop1, pop2) (Fig. Ancient genomes indicate population replacement in Early Neolithic Britain. Here is a sampling of five herbs that have demonstrated potential immune support benefits: 1. The Italian peninsula was previously considered to be another climatic refugium for humans during the LGM. The dates were calibrated using OxCal 4.452 with calibration curve IntCal20 at 95.4% probability53 and when multiple dates were available for the same individual we used the function R_Combine to combine them52. PubMed 1, Extended Data Table 1, Supplementary Data 1.A, Supplementary Information, section1 and Supplementary Fig. The dimensions are calculated using newly reported and previously published hunter-gatherer groups or individuals with more than 30,000 SNPs. Google Scholar. Evol. 272, 288296 (2012). Max Planck Institute for Evolutionary Anthropology. The expansion of farming by9,8, 7.5 and7 kais shown as green shades. Meyer, M. et al. The Solutrean culture is temporally intermediate between the Gravettian and the Magdalenian (or the Badegoulian) cultures, and is found in southwestern and western Europe, which are considered to have been climatic refugia for human populations during the LGM25,26. Big data data warehousing and data science are two sub-tasks of a larger endeavor . Genetics 192, 10651093 (2012). 4b and Supplementary Data 3.C). ADS A 5700 year-old human genome and oral microbiome from chewed birch pitch. Basically, you minimize effort and maximize outcomes. Grizz, Panda i Lodomir maj rne charaktery, ale pomimo odmiennoci potrafi wspdziaa i wspiera si w kopotach. 724703 and no. Nat. In addition to this general data science content, Tina teaches SQL . Nucleic Acids Res. As a general rule of thumb, we start from the simplest issue and gradually increase in complexity. Tina's authentic and engaging delivery style allows her to create original content on topics like how to be more productive, how to learn more efficiently, how to land a job in data science . The oldest individual in the Fournol cluster is Ormesson 2988 from northeastern France (31ka, Early/Middle Gravettian), whereasa Gravettian group from Goyet in Belgium (27ka, Late Gravettian) is found to be a mixture between the Vstonice and Fournol clusters. Tina Huangis a data scientist currently working at a large FAANG enterprise. 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Tina is a data scientist working in tech and does Youtube part time. Tina Huang is a well-known data scientist who has over 10 years of experience on YouTube and has previously worked at a FAANG organization. The resulting GoyetQ2 cluster includes individuals spanning from western France to Poland in the period between 18 and 15ka. You need a lot of information to predict whats going to happen, but then you also need a lot of information to make decisions about what youre going to do. My name is Tina Huang and I'm a data scientist at a FAANG company. Tinas authentic and engaging delivery style allows her to create original content on topics like how to be more productive, how to learn more efficiently, how to land a job in data science, and more. Nowadays, we take it for granted that these features exist, but the integrity of those products is, in fact, a labor of love. The increasing level of admixture between distinct hunter-gatherer populations from around 8ka onwards indicates an intensified mobility of those forager groups. The research team describes a large-scale genetic replacement that may have been caused, in part, by climatic changes that forced people to migrate: "At that time, the climate warmed up quickly and considerably and forests spread across the European continent. Her YouTube channel is dedicated to data and computer science, including how to educate yourself in these topics. 4, 11 (2007). iScience 25, 104244 (2022). Quat. Track your course progress, set daily goals, and make success a routine. Mol. Peltzer, A. et al. The newly generated genotypes were merged with 240 published ancient hunter-gatherer genomes and modern worldwide populations for downstream analyses (Supplementary Data 1.G). Tina Huang Is A Member Of . Single-stranded DNA libraries were built from 30l of DNA extract in the absence of uracil DNA glycosylase (ss_nonUDG) followed by double indexing, using an automated version of the protocols described in61 on the liquid handling system mentioned before. Sci. Harris, K. & Nielsen, R. The genetic cost of Neanderthal introgression. Upper Palaeolithic genomes reveal deep roots of modern Eurasians. By using our site you agree toour A dashed line of 50 cM total ROH is drawn in each panel to help comparison between panels with different y-axis scales. ADS Dismiss. Protoc. Epoxy Flooring UAE; Floor Coating UAE; Self Leveling Floor Coating; Wood Finishes and Coating; Functional Coatings. Views expressed here do not necessarily reflect those of ScienceDaily, its staff, its contributors, or its partners. Dolukhanov, P. in Cultural Transformations and Interactions in Eastern Europe (eds Chapman, J. In article number 2206752, Hao Zeng and co-workers report a soft actuator assembly capable of windassisted dispersal and lift-off/landing action under the control of a light beam.The design is inspired by the seed of dandelion, resembling several biomimetic features, i.e., high porosity, lightweight, and separated vortex ring generation under a steady wind flow. Bold letters refer to (a) mtDNA and (b) Ychr haplogroups, whose boxes are coloured according to the legend in Extended Data Fig. After 7.5ka, as ANF ancestry had reached regions north of the Alps, individuals carrying a hunter-gatherer genetic profile were primarily restricted to the northern fringes of Europe (Fig. Liet. PubMed Curr. 6 Reasons We Just Cant Stop. Wonderful course so far Tina. Correspondence to The length of each coloured bar represents the fraction of individuals carrying the corresponding haplogroup (legend on the right of each panel). Big data data warehousing and data science are two sub-tasks of a larger endeavor called data science, which is a sub-tasks of data science. She then pursued a Masters . HaploGrep 2: mitochondrial haplogroup classification in the era of high-throughput sequencing. She is concise, pragmatic and to the point in the videos and it is easy to follow her lectures. The Gravettian culture was one of the most widely distributed Upper Palaeolithic cultures across western Eurasia before the LGM19. They were linked by a common archaeological culture: they used similar weapons and produced similar portable art. Curr. & Meyer, M. Extraction of highly degraded DNA from ancient bones, teeth and sediments for high-throughput sequencing. 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